Cholesterol regulation of ion channels

Cholesterol binding to ion channels

Numerous studies demonstrated that membrane cholesterol is a major regulator of ion channel function. The goal of this review is to discuss significant advances that have been recently achieved in elucidating the mechanisms responsible for cholesterol regulation of ion channels. The first major insight that comes from growing number of studies that based on the sterol specificity of cholesterol...

Cytoskeleton regulation of ion channels.

C ardiac arrhythmia is one of the leading causes of sudden death in developed countries, and results from abnormal cardiac electric activity. Regular beat-to-beat cardiac excitability requires the coordinated activity of membrane-bound ionophoric proteins that are channels and transporters. Aberrant currents can result from either changes in the gating properties of ionophores or altered traffi...

Cytoskeleton Regulation of Ion Channels Running

Calcium Regulation of Ion Channels in Neurons

Intracellular calcium modulates the activity of a number of voltagedependent ion channels in neurons. This modulation is often functionally important, and can influence the responsiveness of cells to natural inputs. In extreme cases, the regulation of ion channels by intracellular calcium can even determine the pattern of electrical activity of neurons. In this review, I will summarize the role...

G protein regulation of potassium ion channels.